San Francisco 49ers 2025 Future Opponents Schedule

The San Francisco 49ers are heading into the 2025 NFL season with Super Bowl aspirations, and fans are eager to witness another year of high-stakes football. Whether you’re planning to cheer from Levi’s Stadium or travel to support the 49ers on the road, knowing the 49ers' 2025 future opponents is key to planning the perfect football experience.

The 2025 schedule features intense NFC West rivalries, plus marquee matchups against top-tier opponents like the Bears, Titans, and Jaguars at home. On the road, the 49ers will face historic franchises like the Giants and Browns, while also traveling to Houston and Tampa Bay for must-visit destinations.

This guide breaks down the 49ers' 2025 home and away matchups, highlights must-watch games, and provides expert tips on securing San Francisco 49ers tickets, NFL hotels, and all-inclusive 49ers travel packages for an unforgettable football season.

San Francisco 49ers 2025 Home & Away Opponents

San Francisco 49ers Home Games at Levi’s Stadium (Santa Clara, CA):

• Arizona Cardinals
• Los Angeles Rams
• Seattle Seahawks
• Atlanta Falcons
• Carolina Panthers
• Jacksonville Jaguars
• Tennessee Titans
• Chicago Bears

San Francisco 49ers Away Games:

• Arizona Cardinals
• Los Angeles Rams
• Seattle Seahawks
• New Orleans Saints
• Tampa Bay Buccaneers
• Houston Texans
• Indianapolis Colts
• New York Giants
• Cleveland Browns

Key Matchups to Watch in 2025

🔥 San Francisco 49ers vs. Los Angeles Rams – One of the biggest NFC West rivalries, this battle at Levi’s Stadium is a must-watch every season.

🔥 San Francisco 49ers vs. Chicago Bears – A clash of two historic franchises, as the Bears travel to the Bay Area for what could be a high-stakes NFC matchup.

🔥 San Francisco 49ers at New York Giants – A game against the Giants at MetLife Stadium brings back memories of legendary NFC playoff battles.

🔥 San Francisco 49ers at Cleveland Browns – A hard-nosed matchup featuring two of the most physical teams in the league at Cleveland Browns Stadium.

🔥 San Francisco 49ers at Tampa Bay Buccaneers – A coast-to-coast showdown in Florida as the 49ers take on the Buccaneers in what should be an exciting matchup.

Best Road Trip Games for 49ers Fans

🚗 San Francisco 49ers at Los Angeles Rams – A quick trip down the coast to see the 49ers battle the Rams at SoFi Stadium is always an elite road trip.

✈️ San Francisco 49ers at New York Giants – A trip to New York City combined with a 49ers game at MetLife Stadium makes for a great football weekend.

🏟 San Francisco 49ers at Cleveland Browns – Experience one of the toughest fan environments in the league with a trip to Cleveland.

🌴 San Francisco 49ers at Tampa Bay Buccaneers – Florida in the fall? Yes, please! Combine football with a warm-weather vacation in Tampa.

Plan Your 2025 San Francisco 49ers Travel

With a schedule packed with high-profile home games and must-visit road destinations, the San Francisco 49ers 2025 season is shaping up to be one of the most exciting yet. Whether you’re looking to cheer on the 49ers at Levi’s Stadium or travel to some of the NFL’s best cities, now is the time to secure your San Francisco 49ers travel packages.

📍 Get your San Francisco 49ers tickets now and start planning your 2025 49ers football adventure!